Spine neck geometry determines spino-dendritic cross-talk in the presence of mobile endogenous calcium binding proteins

@article{Schmidt2009SpineNG,
  title={Spine neck geometry determines spino-dendritic cross-talk in the presence of mobile endogenous calcium binding proteins},
  author={Hartmut Schmidt and Jens Eilers},
  journal={Journal of Computational Neuroscience},
  year={2009},
  volume={27},
  pages={229-243}
}
Dendritic spines are thought to compartmentalize second messengers like Ca2+. The notion of isolated spine signaling, however, was challenged by the recent finding that under certain conditions mobile endogenous Ca2+-binding proteins may break the spine limit and lead to activation of Ca2+-dependent dendritic signaling cascades. Since the size of spines is variable, the spine neck may be an important regulator of this spino-dendritic crosstalk. We tested this hypothesis by using an… CONTINUE READING