Spindles get the ran around.

  title={Spindles get the ran around.},
  author={Rebecca Heald and Karsten Weis},
  journal={Trends in cell biology},
  volume={10 1},
Despite its fundamental role in cell division, the mitotic spindle remains an enigmatic figure in cell biology. This is due to the complex dynamic behaviour of microtubules, which form the spindle fibres responsible for segregating chromosomes to opposite ends of the cell during mitosis. Recent reports indicate that the small GTPase Ran, which plays a key role in nuclear transport, also has a role in mitosis by regulating microtubule nucleation and/or growth. The race is now on to determine how… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 21 extracted citations


Publications referenced by this paper.
Showing 1-10 of 20 references

Balanced regulation of microtubule dynamics during the cell cycle : a contemporary view

  • S. S. Andersen
  • BioEssays
  • 1999

A model for the proposed roles of different microtubule - based motor proteins in establishing spindle bipolarity

  • C. E. Walczak
  • Curr . Biol .
  • 1998

Similar Papers

Loading similar papers…