Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis.

@article{BurumAuensen2006SpindlePA,
  title={Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis.},
  author={Espen Burum-Auensen and Paula M Deangelis and Aasa R. Schj{\o}lberg and Jo R{\o}islien and Solveig Norheim Andersen and Ole Petter Fraas Clausen},
  journal={Journal of clinical pathology},
  year={2006},
  volume={60 12},
  pages={
          1403-8
        }
}
BACKGROUND Long term ulcerative colitis (UC) increases the risk of colorectal cancer (CRC). DNA aneuploidy is a common feature of both dysplastic and non-dysplastic colonic epithelia from patients with longstanding UC, and is regarded as an early sign of possible malignant transformation. The spindle proteins Aurora A, BUB1B and Mad2 have been implicated as contributors to aneuploidy and carcinogenesis. AIMS To investigate the role of these spindle proteins in relation to DNA aneuploidy and… CONTINUE READING

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