Spindle-pole organization during early mouse development.

  title={Spindle-pole organization during early mouse development.},
  author={L Hiraoka and Wendy Golden and Terry Magnuson},
  journal={Developmental biology},
  volume={133 1},
Spindle-pole organization during early mouse development was examined using a variety of immunological reagents that recognize centrosomal components. Spindle poles of unfertilized eggs and blastocysts were found to react positively with two antisera (centrin and NRS-01), whereas poles of activated eggs and early cleavage-stage embryos were negative when treated with the same sera. In contrast, a third antiserum (5051) showed positive spindle-pole staining throughout the preimplantation stages… CONTINUE READING