Spindle poisons induce allelic loss in mouse lymphoma cells through mitotic non-disjunction.

@article{Honma2001SpindlePI,
  title={Spindle poisons induce allelic loss in mouse lymphoma cells through mitotic non-disjunction.},
  author={Masamitsu Honma and Masaki Momose and Hiroko Sakamoto and Toshio Sofuni and Makoto Hayashi},
  journal={Mutation research},
  year={2001},
  volume={493 1-2},
  pages={101-14}
}
Aneuploidy is an important contributor to reproductive failure and tumor development. It arises spontaneously or as a result of exposure to aneugenic agents through non-disjunction. Two spindle poisons, colchicine (COL) and vinblastine (VBL) are mutagenic in the mouse lymphoma assay (MLA), a gene mutation assay that targets the heterozygous thymidine kinase (tk) gene on chromosome 11 in mouse lymphoma L5178Y tk+/- 3.7.2c cells. To investigate the mechanisms of spindle poison mutagenesis, we… CONTINUE READING
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