Spindle poisons can induce polyploidy by mitotic slippage and micronucleate mononucleates in the cytokinesis-block assay.

@article{Elhajouji1998SpindlePC,
  title={Spindle poisons can induce polyploidy by mitotic slippage and micronucleate mononucleates in the cytokinesis-block assay.},
  author={Azeddine Elhajouji and Margarida Bar{\~a}o da Cunha and Micheline Kirsch-Volders},
  journal={Mutagenesis},
  year={1998},
  volume={13 2},
  pages={193-8}
}
The human in vitro cytokinesis-blocked micronucleus (MN) assay has been extensively used for detection of clastogenic and aneugenic agents. In this test binucleate cells are generally considered to be the main target cell population for assessing genotoxic effect and almost no attention is paid to the biological information contained in mono-nucleate cells. In this study we analysed the frequencies of micronucleate mononucleates in a control population and after in vitro exposure to clastogens… CONTINUE READING