Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.

@article{Quyn2010SpindleOB,
  title={Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.},
  author={Aaron J. Quyn and Paul L. Appleton and Francis A. Carey and Robert J. C. Steele and Nick Barker and Hans Clevers and Rachel A. Ridgway and Owen James Sansom and Inke S. N{\"a}thke},
  journal={Cell stem cell},
  year={2010},
  volume={6 2},
  pages={175-81}
}
The importance of asymmetric divisions for stem cell function and maintenance is well established in the developing nervous system and the skin; however, its role in gut epithelium and its importance for tumorigenesis is still debated. We demonstrate alignment of mitotic spindles perpendicular to the apical surface specifically in the stem cell compartments of mouse and human intestine and colon. This orientation correlates with the asymmetric retention of label-retaining DNA. Both the… CONTINUE READING
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