Spindle-kinetochore attachment requires the combined action of Kin I-like Klp5/6 and Alp14/Dis1-MAPs in fission yeast.

@article{Garca2002SpindlekinetochoreAR,
  title={Spindle-kinetochore attachment requires the combined action of Kin I-like Klp5/6 and Alp14/Dis1-MAPs in fission yeast.},
  author={Miguel Angel Garc{\'i}a and Nirada Koonrugsa and Takashi Toda},
  journal={The EMBO journal},
  year={2002},
  volume={21 22},
  pages={
          6015-24
        }
}
  • Miguel Angel García, Nirada Koonrugsa, Takashi Toda
  • Published in The EMBO journal 2002
  • Medicine, Biology
  • Fission yeast Klp5 and Klp6 belong to the microtubule-destabilizing Kin I family. In klp5 mutants, spindle checkpoint proteins Mad2 and Bub1 are recruited to mitotic kinetochores for a prolonged duration, indicating that these kinetochores are unattached. Further analysis shows that there are kinetochores to which only Bub1, but not Mad2, localizes. These kinetochores are likely to have been captured, yet lack tension. Thus Klp5 and Klp6 play a role in a spindle- kinetochore interaction at dual… CONTINUE READING

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