Spindle checkpoint maintenance requires Ame1 and Okp1.

@article{Pot2005SpindleCM,
  title={Spindle checkpoint maintenance requires Ame1 and Okp1.},
  author={Isabelle Pot and James Knockleby and Victoria Aneliunas and Thao Nguyen and Sonia Ah-Kye and Gregory B Liszt and Michael K. Snyder and Philip A. Hieter and Jackie Vogel},
  journal={Cell cycle},
  year={2005},
  volume={4 10},
  pages={
          1448-56
        }
}
Kinetochore proteins are required for high fidelity chromosome segregation and as a platform for checkpoint signaling. Ame1 is an essential component of the COMA (Ctf19, Okp1, Mcm21, Ame1) sub-complex of the central kinetochore of budding yeast. In this study, we describe the isolation and characterization of an Ame1 conditional mutant, ame1-4. ame1-4 cells exhibit chromosome segregation defects and Mad2-dependent cell cycle delay similar to okp1-5 cells. However, the viability of ame1-4 cells… CONTINUE READING

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