Spindle cell cancer of bladder during cyclophosphamide therapy for Wegener's granulomatosis.

  title={Spindle cell cancer of bladder during cyclophosphamide therapy for Wegener's granulomatosis.},
  author={S. Chasko and J. G. Keuhnelian and W. T. Gutowski and G. Gray},
  journal={The American journal of surgical pathology},
  volume={4 2},
  • S. Chasko, J. G. Keuhnelian, +1 author G. Gray
  • Published 1980
  • Medicine
  • The American journal of surgical pathology
  • A 38-year-old woman with long-standing Wegener's granulomatosis had remission with cyclophosphamide therapy after failure of response to other agents. Severe cystitis with massive blood loss necessitated a cystectomy. The bladder contained an unsuspected neoplasm, histologically resembling leiomyosarcoma, but desmosomes seen on electron-microscopic examination suggested that this was a spindle cell carcinoma. The findings document occurrence of cyclophosphamide related bladder cancer in a… CONTINUE READING
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