Spindle assembly checkpoint satisfaction occurs via end-on but not lateral attachments under tension

@inproceedings{Kuhn2017SpindleAC,
  title={Spindle assembly checkpoint satisfaction occurs via end-on but not lateral attachments under tension},
  author={J. L. Kuhn and Sophie Dumont},
  booktitle={The Journal of cell biology},
  year={2017}
}
To ensure accurate chromosome segregation, the spindle assembly checkpoint (SAC) prevents anaphase until all kinetochores attach to the spindle. What signals the SAC monitors remains unclear. We do not know the contributions of different microtubule attachment features or tension from biorientation to SAC satisfaction nor how these possible cues change… CONTINUE READING