Spinal strychnine alters response properties of nociceptive-specific neurons in rat medial thalamus.

@article{Sherman1997SpinalSA,
  title={Spinal strychnine alters response properties of nociceptive-specific neurons in rat medial thalamus.},
  author={Spencer E. Sherman and Lei Luo and Jonathan O. Dostrovsky},
  journal={Journal of neurophysiology},
  year={1997},
  volume={78 2},
  pages={628-37}
}
Experiments in both conscious and anesthetized animals indicate that intrathecal (i.t.) strychnine (STR; glycine receptor antagonist) produces acute, reversible allodynia, as evidenced by inappropriate behavioral and autonomic responses to cutaneous tactile stimuli. Although STR is known to produce disinhibition of afferent input to the spinal cord, changes in spinal reflexes cannot fully explain the complex behaviors observed following i.t. STR. Which supraspinal sites are involved in STR… CONTINUE READING