Spinal noradrenergic pathways and pressor responses to central angiotensin II.

@article{Elghozi1990SpinalNP,
  title={Spinal noradrenergic pathways and pressor responses to central angiotensin II.},
  author={Jean Luc Elghozi and G A Head},
  journal={The American journal of physiology},
  year={1990},
  volume={258 1 Pt 2},
  pages={H240-6}
}
We have investigated the contribution of spinal noradrenergic (NA) pathways to the central pressor effects of angiotensin II (ANG II) in conscious rabbits with intact baroreceptors and after sinoaortic denervation (SAD). Very low intracisternal (ic) doses of ANG II [half maximum dose (ED50) = 6 x 10(-15) mol] produced increases in mean arterial pressure (MAP) and decreases in heart rate. Pressor responses to intracisternal ANG II were markedly reduced by 100 pmol of the ANG II antagonist… CONTINUE READING