Spinal modulation of the induction of central sensitization.

  title={Spinal modulation of the induction of central sensitization.},
  author={Richard J. Traub},
  journal={Brain research},
  volume={778 1},
Peripheral tissue injury results in a change in the excitability of spinal dorsal horn neurons, central sensitization, and the behavioral correlate, hyperalgesia. It is proposed here that a dynamic balance exists between excitatory and inhibitory synaptic input to the spinal dorsal horn that functions to prevent central sensitization following brief, mild, noxious stimulation. Following more severe stimulation and injury, there is a loss of these inhibitory mechanisms that allow central… CONTINUE READING
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