Spinal mechanism of standard analgesics: evaluation using mouse models of allodynia.


Spinal neurotransmission plays an important role in the perception of pain signaling. In the present study, we investigated the spinal anti-nociceptive mechanism of current standard analgesics in mouse models of tactile allodynia induced by intrathecal administration of N-methyl-D-aspartic acid (NMDA), prostaglandin E2 (PGE2), and bicuculline. NMDA-induced… (More)
DOI: 10.1016/j.ejphar.2010.02.025