Spinal mechanism of micturition reflex inhibition by naftopidil in rats.

  title={Spinal mechanism of micturition reflex inhibition by naftopidil in rats.},
  author={K. Sugaya and S. Nishijima and K. Kadekawa and Katsuhiro Ashitomi and T. Ueda and H. Yamamoto},
  journal={Life sciences},
  volume={116 2},
  • K. Sugaya, S. Nishijima, +3 authors H. Yamamoto
  • Published 2014
  • Medicine
  • Life sciences
  • AIM We investigated the spinal mechanism through which naftopidil inhibits the micturition reflex by comparing the effects of noradrenaline and naftopidil in rats. METHODS The following were investigated: the influence of oral naftopidil on plasma monoamine and amino acid levels, the distribution of oral 14C-naftopidil, the effects of intravenous (IV) or intrathecal (IT) injection of noradrenaline or naftopidil on isovolumetric bladder contractions, amino acid levels in the lumbosacral spinal… CONTINUE READING
    19 Citations
    Effect of naftopidil on brain noradrenaline-induced decrease in arginine-vasopressin secretion in rats.
    • 2
    • PDF
    Effects of High Concentrations of Naftopidil on Dorsal Root-Evoked Excitatory Synaptic Transmissions in Substantia Gelatinosa Neurons In Vitro
    • 4
    • PDF
    Long-term administration of alpha-1 blocker can reverse the micturition pattern in a bladder outlet obstruction murine model.
    • T. Kitta, H. Chiba, +8 authors N. Shinohara
    • Medicine
    • International journal of urology : official journal of the Japanese Urological Association
    • 2020


    Central nervous control of micturition and urine storage.
    • 91
    • PDF
    Naftopidil inhibits 5-hydroxytryptamine-induced bladder contraction in rats.
    • 21