Spinal manipulative therapy reduces inflammatory cytokines but not substance P production in normal subjects.

OBJECTIVE To examine the effect of a single spinal manipulation therapy (SMT) on the in vitro production of inflammatory cytokines, tumor necrosis factor alpha, and interleukin (IL) 1beta, in relation to the systemic (in vivo) levels of neurotransmitter substance P (SP). METHODS Sixty-four asymptomatic subjects were assigned to SMT, sham manipulation, or… CONTINUE READING