Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents.

  title={Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents.},
  author={Grewo Lim and Shuxing Wang and Yi Zhang and Yinghong Tian and Jianren Mao},
  journal={The Journal of clinical investigation},
  volume={119 2},
Pain after nerve injury, a phenomenon referred to as neuropathic pain, is a debilitating clinical condition, but the underlying mechanisms remain unclear. As leptin, an adipocytokine produced mainly by nonneuronal tissue, has been implicated in the regulation of neuronal functions, we examined the role of leptin in neuropathic pain using a rat model of the condition chronic constriction sciatic nerve injury (CCI). We report that leptin critically contributed to pain behaviors following CCI… CONTINUE READING


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