Spinal interleukin-1beta reduces inflammatory pain.

  title={Spinal interleukin-1beta reduces inflammatory pain.},
  author={A J Souter and Mary G. Garry and Darrell L. Tanelian},
  volume={86 1-2},
Inflammation or injury often lead to chronic pain states such as hyperalgesia where the perception of a normally painful stimulus is significantly exaggerated. Interleukin-1beta (IL-1beta) is a cytokine that is an important mediator of the inflammatory response. In addition, IL-1beta has been implicated in the modulation of pain transmission in both the peripheral and central nervous systems. We evaluated the spinal effect of this cytokine in the presence and absence of a peripheral carrageenan… CONTINUE READING
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