Spinal fluid CRF reduction in Alzheimer's disease.

  title={Spinal fluid CRF reduction in Alzheimer's disease.},
  author={Maral M Mouradian and Johko Farah and Erich Mohr and Giovanni Fabbrini and Thomas L. O'Donohue and Thomas N. Chase},
  volume={8 4},
Abnormalities in several neurotransmitters, including neuropeptides, have been found in postmortem studies of Alzheimer's disease (AD). Recently, corticotropin-releasing factor (CRF) was found to be diminished in cerebral cortex. In this study spinal fluid CRF-immunoreactivity (CRF-I) was determined in 16 patients with mild to moderate AD and 9 age-matched controls. Mean CRF-I levels were significantly lower in Alzheimer patients compared with controls. Furthermore, a tendency for a CRF-I… CONTINUE READING
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