Spinal endomorphin 2 antinociception and the mechanisms that produce it are both sex- and stage of estrus cycle-dependent in rats.

@article{Liu2013SpinalE2,
  title={Spinal endomorphin 2 antinociception and the mechanisms that produce it are both sex- and stage of estrus cycle-dependent in rats.},
  author={Nai-Jiang Liu and Alan R. Gintzler},
  journal={The journal of pain : official journal of the American Pain Society},
  year={2013},
  volume={14 11},
  pages={1522-30}
}
UNLABELLED Endomorphin 2 (EM2) is the predominant endogenous mu-opioid receptor (MOR) ligand in the spinal cord. Given its endogenous presence, antinociceptive responsiveness to the intrathecal application of EM2 most likely reflects its ability to modulate nociception when released in situ. In order to explore the physiological pliability of sex-dependent differences in spinal MOR-mediated antinociception, we investigated the antinociception produced by intrathecal EM2 in male, proestrus… CONTINUE READING
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