Spinal delta-opioid receptors mediate suppression of systemic SNC80 on excitability of the flexor reflex in normal and inflamed rat.

  title={Spinal delta-opioid receptors mediate suppression of systemic SNC80 on excitability of the flexor reflex in normal and inflamed rat.},
  author={Chang Qing Cao and Y. Hong and Andy Dray and Martin N. Perkins},
  journal={European journal of pharmacology},
  volume={418 1-2},

Up-regulation and trafficking of d opioid receptor in a model of chronic inflammation: implications for pain control

It is demonstrated that CFA induces an up-regulation and increased membrane targeting of d opioids receptors in the dorsal spinal cord which may account for the enhanced antinociceptive effects of d opioid receptor agonists in chronic inflammatory pain models.

Pro-nociceptive effects of neuromedin u in rat

δ-Opioid Mechanisms for ADL5747 and ADL5859 Effects in Mice: Analgesia, Locomotion, and Receptor Internalization

Both ADL5859 and ADL5747 showed efficient pain-reducing properties in the two models of chronic pain, and the lack of in vivo receptor internalization and locomotor activation, typically induced by SNC80, suggests agonist-biased activity at the receptor for the two drugs.

Participation of the endogenous opioid and cannabinoid systems in neuropathic pain

The results show that DOR and CB2 may be pharmacological targets for the development of new drugs with analgesic activity, but devoid of the psychotropic side effects of traditional opioids and cannabinoid agonists.

Molecular Pharmacology of δ-Opioid Receptors

This review addresses DOPrs from the perspective of cellular and molecular determinants of their pharmacological diversity, and current knowledge on DOPr targeting to the membrane is examined as a means of understanding how these receptors are especially active in chronic pain management.

Delta opioid receptor analgesia: recent contributions from pharmacology and molecular approaches

These tools for in-vivo research, and proposed mechanisms at molecular level, have tremendously increased understanding of &dgr; receptor physiology, and contribute to designing innovative strategies for the treatment of chronic pain and other diseases such as mood disorders.

Delta Opioid Receptor Expression and Function in Primary Afferent Somatosensory Neurons.

This work describes how DOR modulates opening of voltage-gated calcium channels to control glutamatergic neurotransmission between somatosensory neurons and postsynaptic neurons in the spinal cord dorsal horn and discusses other potential signaling mechanisms, including those involving potassium channels, which DOR may engage to fine tune somatosensation.



Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse.

The opioid receptors involved in the mediation of thermal analgesia and inhibition of gastrointestinal transit at the spinal and supraspinal levels were studied in unanesthetized mice and receptor-selective compounds found to produce analgesia after i.c.v. administration.

Differential effects of intrathecally administered delta and mu opioid receptor agonists on formalin-evoked nociception and on the expression of Fos-like immunoreactivity in the spinal cord of the rat.

The results provide new evidence that the antinociception produced by i.t. administered DAMGO suggests that a direct spinal action contributes to the inhibition of noxious stimulus-evoked Fos-LI in the spinal cord produced by systemically administered mu opioid receptor agonists such as morphine.

Spinal opioid delta antinociception in the mouse: mediation by a 5'-NTII-sensitive delta receptor subtype.

The present study has extended the characterization of delta-mediated antinociception effects of DPDPE and DELT after i.t. administration in mice using pretreatment with DALCE and 5'-NTII in order to selectively antagonize the delta subtypes.

Evidence for delta opioid receptor subtypes in rat spinal cord: studies with intrathecal naltriben, cyclic[D-Pen2, D-Pen5] enkephalin and [D-Ala2, Glu4]deltorphin.

It is suggested that DELT and DPDPE act at different delta opioid receptor subtypes in the rat spinal cord and 3 micrograms of NTB can distinguish these receptor sub types, and activation of either delta-1 or delta-2 receptors is sufficient to produce antinociception in the tail-flick test.

Activation of spinal delta-1 or delta-2 opioid receptors reduces carrageenan-induced hyperalgesia in the rat.

Although NTB distinguishes between delta-1 and delta-2 opioid receptors, high doses may not effectively distinguish between delta and mu receptors, consistent with characterization of NTB as a selective delta- 2 receptor antagonist.

Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists.

The potentiating effects of delta agonists on mu-mediated analgesia are due to an increase in the release of endogenous CCK interacting with CCK-A andCCK-B receptors and resulting in positive and negative regulation of the endogenous opioid system.

Opioid pharmacology of the antinociceptive effects of loperamide in mice

The results indicate that the antinociceptive effects of loperamide in mice are mediated, at least in part, by opioid receptors; however, these receptors are distinct from the opioid receptors mediating the effects of morphine, U69,593 and BW 373U86.