Spinal delta-opioid receptors mediate suppression of systemic SNC80 on excitability of the flexor reflex in normal and inflamed rat.

@article{Cao2001SpinalDR,
  title={Spinal delta-opioid receptors mediate suppression of systemic SNC80 on excitability of the flexor reflex in normal and inflamed rat.},
  author={Chang Qing Cao and Y. Hong and Andy Dray and Martin N. Perkins},
  journal={European journal of pharmacology},
  year={2001},
  volume={418 1-2},
  pages={
          79-87
        }
}
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18 Citations

Up-regulation and trafficking of d opioid receptor in a model of chronic inflammation: implications for pain control

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Pro-nociceptive effects of neuromedin u in rat

Selective depression of nociceptive responses of dorsal horn neurones by SNC 80 in a perfused hindquarter preparation of adult mouse

δ-Opioid Mechanisms for ADL5747 and ADL5859 Effects in Mice: Analgesia, Locomotion, and Receptor Internalization

Both ADL5859 and ADL5747 showed efficient pain-reducing properties in the two models of chronic pain, and the lack of in vivo receptor internalization and locomotor activation, typically induced by SNC80, suggests agonist-biased activity at the receptor for the two drugs.

Up-regulation and trafficking of δ opioid receptor in a model of chronic inflammation: implications for pain control

Non-peptidic delta-opioid receptor antagonists suppress mitogen-induced tryptophan degradation in peripheral blood mononuclear cells in vitro.

Participation of the endogenous opioid and cannabinoid systems in neuropathic pain

The results show that DOR and CB2 may be pharmacological targets for the development of new drugs with analgesic activity, but devoid of the psychotropic side effects of traditional opioids and cannabinoid agonists.

Molecular Pharmacology of δ-Opioid Receptors

This review addresses DOPrs from the perspective of cellular and molecular determinants of their pharmacological diversity, and current knowledge on DOPr targeting to the membrane is examined as a means of understanding how these receptors are especially active in chronic pain management.

Delta opioid receptor analgesia: recent contributions from pharmacology and molecular approaches

These tools for in-vivo research, and proposed mechanisms at molecular level, have tremendously increased understanding of &dgr; receptor physiology, and contribute to designing innovative strategies for the treatment of chronic pain and other diseases such as mood disorders.

Delta Opioid Receptor Expression and Function in Primary Afferent Somatosensory Neurons.

This work describes how DOR modulates opening of voltage-gated calcium channels to control glutamatergic neurotransmission between somatosensory neurons and postsynaptic neurons in the spinal cord dorsal horn and discusses other potential signaling mechanisms, including those involving potassium channels, which DOR may engage to fine tune somatosensation.

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