Spinal cord-transected mice learn to step in response to quipazine treatment and robotic training.

@article{Fong2005SpinalCM,
  title={Spinal cord-transected mice learn to step in response to quipazine treatment and robotic training.},
  author={Andy J. Fong and Lance Cai and Chad K. Otoshi and David J. Reinkensmeyer and Joel W. Burdick and Roland R. Roy and V. Reggie Edgerton},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 50},
  pages={
          11738-47
        }
}
In the present study, concurrent treatment with robotic step training and a serotonin agonist, quipazine, generated significant recovery of locomotor function in complete spinal cord-transected mice (T7-T9) that otherwise could not step. The extent of recovery achieved when these treatments were combined exceeded that obtained when either treatment was applied independently. We quantitatively analyzed the stepping characteristics of spinal mice after alternatively administering no training… CONTINUE READING

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