Spinal cord stimulation induces c-Fos expression in the dorsal horn in rats with neuropathic pain after partial sciatic nerve injury.

@article{Smits2009SpinalCS,
  title={Spinal cord stimulation induces c-Fos expression in the dorsal horn in rats with neuropathic pain after partial sciatic nerve injury.},
  author={Helwin Smits and M. van Kleef and Wiel H H Honig and Job Gerver and Philipp Gobrecht and Elbert A. J. Joosten},
  journal={Neuroscience letters},
  year={2009},
  volume={450 1},
  pages={70-3}
}
Spinal cord stimulation (SCS) is an established treatment for intractable neuropathic pain, especially CRPS-1. The mechanisms of action of SCS have only been partly elucidated and include suppression of the hyper-excitability of the Wide Dynamic Range neurons and a GABA increase in the dorsal horn. In the present study we demonstrate an increase of c-Fos immunoreactive cells in the dorsal horn after SCS, suggesting early cellular activation that may preclude earlier described… CONTINUE READING