Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis

@inproceedings{Apolloni2014SpinalCP,
  title={Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis},
  author={Savina Apolloni and Susanna Amadio and Chiara Parisi and Alessandra Matteucci and Rosa Luisa Potenza and Monica Armida and Patrizia Popoli and Nadia D’Ambrosi and Cinzia Volont{\'e}},
  booktitle={Disease models & mechanisms},
  year={2014}
}
In recent years there has been an increasing awareness of the role of P2X7, a receptor for extracellular ATP, in modulating physiopathological mechanisms in the central nervous system. In particular, P2X7 has been shown to be implicated in neuropsychiatry, chronic pain, neurodegeneration and neuroinflammation. Remarkably, P2X7 has also been shown to be a 'gene modifier' in amyotrophic lateral sclerosis (ALS): the receptor is upregulated in spinal cord microglia in human and rat at advanced… CONTINUE READING