Spinal cord magnetic resonance imaging in autosomal dominant hereditary spastic paraplegia

@article{Hedera2005SpinalCM,
  title={Spinal cord magnetic resonance imaging in autosomal dominant hereditary spastic paraplegia},
  author={Peter Hedera and Odd Petter Eldevik and Pavel V Maly and Shirley R Rainier and John K. Fink},
  journal={Neuroradiology},
  year={2005},
  volume={47},
  pages={730-734}
}
Hereditary spastic paraplegia (HSP) is a genetically heterogeneous group of neurodegenerative disorders characterized by progressive lower extremity weakness and spasticity. HSP pathology involves axonal degeneration that is most pronounced in the terminal segments of the longest descending (pyramidal) and ascending (dorsal columns) tracts. In this study, we compared spinal cord magnetic resonance imaging (MRI) in 13 HSP patients with four different types of autosomal dominant hereditary… 
MR Imaging Findings in Autosomal Recessive Hereditary Spastic Paraplegia
TLDR
The MR imaging findings of HSP are nonspecific and variable; however, the most prominent features include atrophy of the corpus callosum, T2 signal intensity in the posterior limb of the internal capsule, and spinal cord atrophy.
Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms
  • J. Fink
  • Biology, Medicine
    Acta Neuropathologica
  • 2013
TLDR
Hereditary spastic paraplegia is a syndrome designation describing inherited disorders in which lower extremity weakness and spasticity are the predominant symptoms and emerging concepts of this large group of clinically similar disorders are highlighted.
Neuroimaging in Hereditary Spastic Paraplegias: Current Use and Future Perspectives
TLDR
The current use and future perspectives of MRI in the context of HSP are discussed, with quantitative spinal cord morphometry and diffusion tensor imaging look promising tools to uncover the pathophysiology and to track progression of these diseases.
Genetic origin of patients having spastic paraplegia with or without other neurologic manifestations
TLDR
HSP had widespread clinical and genetic heterogeneity, and leukodystrophy, hereditary ataxia, Charcot-Marie-Tooth atrophy and homocysteine remethylation disorders accounted for a significant proportion of the proposed HSP.
Hereditary spastic paraplegia: a clinical and epidemiological study of a Brazilian pediatric population.
TLDR
In children with spastic paraplegia, HSP must be considered whenever similar pathologies, mainly diplegic cerebral palsy, are ruled out.
Proton magnetic resonance spectroscopy and cognition in patients with spastin mutations
Hereditary Spastic Paraplegia: Beyond Clinical Phenotypes toward a Unified Pattern of Central Nervous System Damage.
TLDR
The detection of a distributed pattern of central nervous system damage in patients with pure and complicated HSP suggests that the "primary" corticospinal tract involvement known to occur in these patients may be associated with a neurodegenerative process, which spreads out to extramotor regions, likely via anatomic connections.
Hereditary spastic paraplegia
TLDR
The target of this review article is to provide a comprehensive overview of the HSP classification, neuropathology, and differential diagnosis.
Neuroimaging patterns in paediatric onset hereditary spastic paraplegias
Ascending Axonal Degeneration of the Corticospinal Tract in Pure Hereditary Spastic Paraplegia: A Cross-Sectional DTI Study
TLDR
DTI metrics of the corticospinal tract from the internal capsule to the cervical spine suggest microstructural damage and axonal degeneration of motor neurons in patients with pure hereditary spastic paraplegia using high angular resolution diffusion tensor imaging.
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