Spinal cord lesions in sporadic Parkinson’s disease

  title={Spinal cord lesions in sporadic Parkinson’s disease},
  author={Kelly del Tredici and Heiko Braak},
  journal={Acta Neuropathologica},
In this autopsy-based study, α-synuclein immunohistochemistry and lipofuscin pigment-Nissl architectonics in serial sections of 100 μm thickness were used to investigate the spinal cords and brains of 46 individuals: 28 patients with clinically and neuropathologically confirmed Parkinson’s disease, 6 cases with incidental Lewy body disease, and 12 age-matched controls. α-Synuclein inclusions (particulate aggregations, Lewy neurites/bodies) in the spinal cord were present between… CONTINUE READING
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