Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways.

@article{Wu2014SpinalCI,
  title={Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways.},
  author={Junfang Wu and Zaorui Zhao and Boris E Sabirzhanov and Bogdan A Stoica and Alok Kumar and Tao Luo and Jacob W. Skovira and Alan I. Faden},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 33},
  pages={10989-1006}
}
Experimental spinal cord injury (SCI) causes chronic neuropathic pain associated with inflammatory changes in thalamic pain regulatory sites. Our recent studies examining chronic pain mechanisms after rodent SCI showed chronic inflammatory changes not only in thalamus, but also in other regions including hippocampus and cerebral cortex. Because changes appeared similar to those in our rodent TBI models that are associated with neurodegeneration and neurobehavioral dysfunction, we examined… CONTINUE READING
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