Spinal cord gray matter atrophy correlates with multiple sclerosis disability.

  title={Spinal cord gray matter atrophy correlates with multiple sclerosis disability.},
  author={Regina Schlaeger and Nico Papinutto and Valentina Panara and Carolyn J. Bevan and Iryna Lobach and M. Bucci and Eduardo Caverzasi and Jeffrey M Gelfand and Ari J Green and Kesshi Jordan and W Stern and Hans-Christian von B{\"u}dingen and Emmanuelle L. Waubant and Alyssa H. Zhu and Douglas S. Goodin and Bruce A. C. Cree and Stephen L. Hauser and Roland G. Henry},
  journal={Annals of neurology},
  volume={76 4},
OBJECTIVE In multiple sclerosis (MS), cerebral gray matter (GM) atrophy correlates more strongly than white matter (WM) atrophy with disability. The corresponding relationships in the spinal cord (SC) are unknown due to technical limitations in assessing SC GM atrophy. Using phase-sensitive inversion recovery (PSIR) magnetic resonance imaging, we determined the association of the SC GM and SC WM areas with MS disability and disease type. METHODS A total of 113 MS patients and 20 healthy… CONTINUE READING


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