Spinal cord dynorphin may modulate nociception via a kappa-opioid receptor in chronic arthritic rats.

@article{Millan1985SpinalCD,
  title={Spinal cord dynorphin may modulate nociception via a kappa-opioid receptor in chronic arthritic rats.},
  author={M. J. Millan and M. H. Millan and C. W. T. Pilcher and Andrzej Członkowski and A. Herz and F. C. Colpaert},
  journal={Brain research},
  year={1985},
  volume={340 1},
  pages={156-9}
}
Inoculation of rats with Mycobacterium butyricum produced an arthritis of the limbs which revealed an enhanced sensitivity to noxious mechanical pressure (hyperalgesia). Arthritic rats displayed a pronounced rise in immunoreactive dynorphin in lumbo-sacral spinal cord which correlated both with the intensity and time-course of this hyperalgesia. MR-2266, a relatively preferential antagonist at the chi-opioid receptor (at which dynorphin is considered to act) potentiated this hyperalgesia. In… CONTINUE READING
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