Spinal cord control of ejaculation

@article{Allard2004SpinalCC,
  title={Spinal cord control of ejaculation},
  author={Julien Allard and William A. Truitt and Kevin E. Mckenna and Lique M Coolen},
  journal={World Journal of Urology},
  year={2004},
  volume={23},
  pages={119-126}
}
Ejaculation is a reflex mediated by a spinal control center, referred to as a spinal ejaculation generator. During intercourse, the spinal ejaculation generator integrates the sensory inputs that are necessary to trigger ejaculation. At the time of ejaculation, it coordinates the sympathetic, parasympathetic, and somatic outflow to induce the two phases of ejaculation, i.e. emission and expulsion. It also provides the brain with signals related to the occurrence of ejaculation. Experimental and… Expand
A pivotal role of lumbar spinothalamic cells in the regulation of ejaculation via intraspinal connections.
TLDR
These data demonstrate that LSt cells are essential for ejaculatory, but not erectile reflexes, as previously reported for mating animals. Expand
Activation of MAP kinase in lumbar spinothalamic cells is required for ejaculation.
TLDR
Results indicate that the MAP kinase signaling pathway is activated in LSt cells following ejaculation in mating animals or induced by DPN stimulation in anesthetized, spinalized animals, and demonstrate that ERK activation in L St cells is essential for ejaculation. Expand
Activation of NMDA receptors in lumbar spinothalamic cells is required for ejaculation.
TLDR
It is demonstrated that glutamate, via activation of NMDA receptors in LSt cells, is a key afferent signal for ejaculation. Expand
Spinal Cord Control of Ejaculatory Reflexes in Male Rats
TLDR
The studies in this thesis further clarified the mechanisms involved in the spinal cord control of ejaculation in male rats and represent an initial but pivotal first step towards the recovery of ejaculatory function after chronic spinal cord injury. Expand
Central neurophysiology and dopaminergic control of ejaculation
TLDR
A better understanding of DA incerto-hypothalamic pathways and targeting brain DA receptor subtypes mediating ejaculation (especially D(3) receptors) will benefit the development of new pharmacological strategies to treat ejaculatory dysfunction including PE. Expand
Activation of gastrin-releasing peptide receptors in the lumbosacral spinal cord is required for ejaculation in male rats.
TLDR
Data support a critical role for GRP for control of the emission and expulsion phases of ejaculation in male rats by acting in LSt target areas in the lumbosacral spinal cord. Expand
THE PHYSIOLOGY AND ECOPHYSIOLOGY OF EJACULATION
TLDR
There is a reflection of the so-called human ejaculatory disturbances, which from an ecophysiolgical perspective could represent advantages instead of sexual malfunction as are recognize under the medical view. Expand
Direct brain projections onto the spinal generator of ejaculation in the rat
TLDR
New insights are provided regarding the anatomical support for the brain control of ejaculation via direct influences onto the SGE through retrograde and anterograde approaches in adult male rats. Expand
Somatic genital reflexes in rats with a nod to humans: Anatomy, physiology, and the role of the social neuropeptides
TLDR
The importance of the "social neuropeptides" oxytocin and vasopressin in the regulation of somatic genital reflexes, and associated sociosexual behaviors, is emerging and has implications for understanding how nervous systems generate sexual behavior but also provides treatment targets for sexual dysfunction in people. Expand
Chronic spinal cord injury reduces gastrin releasing peptide in the spinal ejaculation generator in male rats.
TLDR
Chronic contusion injury decreased immunoreactivity for GRP in LSt cell soma, but didn't affect LSt neurons per se or LSt connections within the SEG, suggesting that LSt cells are not ablated by SCI. Expand
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References

SHOWING 1-10 OF 74 REFERENCES
Central neural regulation of penile erection
TLDR
The shift from flaccidity to erection suggests relations among these neuronal populations in response to a variety of informations, and a spinal network consisting of primary afferents from the genitals, spinal interneurons and sympathetic, parasympathetic and somatic nuclei is hypothesize. Expand
A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes
TLDR
The hypothesis that 5-HT is involved in the descending inhibition of spinal sexual reflexes is supported by anatomical and pharmacological evidence presented and the term coitus reflex is used to describe this response. Expand
Identification of a Potential Ejaculation Generator in the Spinal Cord
TLDR
It is suggested that this population of lumbar spinothalamic cells plays a pivotal role in generation of ejaculatory behavior and may be part of a spinal ejaculation generator. Expand
Muscarinic mediation of the urethro genital reflex in spinal cord-transected rats
TLDR
It can be speculated that muscarinic receptor stimulation is involved in the elicitation of UGR in anesthetized and spinal cord-transected rats. Expand
Evidence for the involvement of a spinal pattern generator in the control of the genital motor pattern of ejaculation
TLDR
Evidence is obtained that supports the notion that a CPG produces the rhythmic ejaculatory motor pattern registered during fictive ejaculation. Expand
Brain Activation during Human Male Ejaculation
TLDR
Insight is provided into which regions in the human brain play a primary role in ejaculation, and the results might have important implications for understanding of how human ejaculation is brought about, and for the ability to improve sexual function and satisfaction in men. Expand
Activation of a Subset of Lumbar Spinothalamic Neurons after Copulatory Behavior in Male But Not Female Rats
TLDR
It is demonstrated that a specific subpopulation of spinothalamic neurons signals information associated with ejaculation, located in laminas 7 and 10 of the lumbar segments 3 and 4. Expand
Neural regulation of the vas deferens in the rat: an electrophysiological analysis.
TLDR
Insight is provided into the organization of afferents in the DNP and efferents conveyed by autonomic pathways that regulate male reproduction and evoked volleys with latencies of 10-30 ms in vasal nerves. Expand
Effects of acute and chronic midthoracic spinal cord injury on neural circuits for male sexual function. I. Ascending pathways.
TLDR
Previous data on ascending projections from female reproductive organs within the dorsal columns and DLQ to other caudal brain stem nuclei, provide evidence for ascending pathways conveying nociceptive information centrally via the DLQ, which differs from the traditionally recognized spinal gray-VLQ pathway, which is known to convey nocICEptive information from cutaneous regions of the body. Expand
Electrical stimulation of the dorsal nerve of the penis evokes reflex tonic erections of the penile body and reflex ejaculatory responses in the spinal rat.
TLDR
The observations suggest that reflex bulbospongiosus muscle activity, flips and ejaculations are a single complex reflex response, which the present model may prove useful for the investigation of Neurogenic erectile dysfunction, and of neurogenic ejaculatory disorders. Expand
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5
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