Spinal cord NMDA receptor-mediated activation of mammalian target of rapamycin is required for the development and maintenance of bone cancer-induced pain hypersensitivities in rats.

@article{Shih2012SpinalCN,
  title={Spinal cord NMDA receptor-mediated activation of mammalian target of rapamycin is required for the development and maintenance of bone cancer-induced pain hypersensitivities in rats.},
  author={Ming-Hung Shih and Sheng-Chin Kao and Wei Wang and Myron Yaster and Yuan-Xiang Tao},
  journal={The journal of pain : official journal of the American Pain Society},
  year={2012},
  volume={13 4},
  pages={338-49}
}
UNLABELLED Mammalian target of rapamycin (mTOR) controls mRNA translation and is critical for neuronal plasticity. However, how it participates in central sensitization underlying chronic pain is unclear. Here, we show that NMDA receptors are required for the functional role of spinal cord mTOR in bone cancer pain induced by injecting prostate cancer cells (PCCs) into the tibia. Intrathecal rapamycin, a specific mTOR inhibitor, dose dependently attenuated the development and maintenance of PCC… CONTINUE READING