Spinal controlled delivery of bupivacaine from DL-lactic acid oligomer microspheres.

@article{Corre1995SpinalCD,
  title={Spinal controlled delivery of bupivacaine from DL-lactic acid oligomer microspheres.},
  author={Pascal Le Corre and J. P. Est{\`e}be and François Chevanne and Yannick Mall{\'e}dant and Roger Le Verge},
  journal={Journal of pharmaceutical sciences},
  year={1995},
  volume={84 1},
  pages={
          75-8
        }
}
Bupivacaine-loaded microspheres made from DL-polylactic acid oligomers of different molecular weights (MW 2000 and 9000 g/mol, named PLA 2000 and PLA 9000, respectively) which displayed different in vitro release profiles were administered via the spinal route to rabbits. In comparison to the drug administered as a solution (2 mg as equivalent base), PLA 2000 and PLA 9000 microspheres (10 mg as equivalent base) led to a slower uptake of the drug in the systemic circulation, as suggested by the… CONTINUE READING