Spinal clonidine inhibits neural firing in locus coeruleus.


Intrathecally-administered clonidine inhibited the spontaneous firing of single neurons in the pontine nucleus locus coeruleus of rats. Such inhibition of neuron firing was not observed when the non-lipophilic alpha 2 adrenoceptor agonist (oxymetazoline) was administered intrathecally. It is concluded that lipophilic drugs like clonidine, when administered… (More)


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@article{Marwaha1983SpinalCI, title={Spinal clonidine inhibits neural firing in locus coeruleus.}, author={Jwaharlal Marwaha and John H. Kehne and Randall L. Commissaris and Joan M. Lakoski and Wesley Shaw and Mary Ann Davis}, journal={Brain research}, year={1983}, volume={276 2}, pages={379-83} }