Spinal cannabinoid CB2 receptors as a target for neuropathic pain: an investigation using chronic constriction injury.

@article{Brownjohn2012SpinalCC,
  title={Spinal cannabinoid CB2 receptors as a target for neuropathic pain: an investigation using chronic constriction injury.},
  author={P. W. Brownjohn and John Clive Ashton},
  journal={Neuroscience},
  year={2012},
  volume={203},
  pages={180-93}
}
Agonists for the cannabinoid CB2 receptor are antinociceptive in several rodent models and several reports have suggested that the target for these drugs is CB2 expressed in the spinal cord pain pathway. After confirming the efficacy of a systemically delivered CB2-selective agonist, GW405833, we tested this hypothesis by administering the CB2 agonists GW405833 and JWH-133, via intrathecal cannulation, to the lumbar spinal cord of rats that had undergone chronic constriction injury to induce… CONTINUE READING