Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38

@article{Svensson2005SpinalBO,
  title={Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38},
  author={Camilla I Svensson and Maria Sch{\"a}fers and Toni L. Jones and Henry C. Powell and Linda S. Sorkin},
  journal={Neuroscience Letters},
  year={2005},
  volume={379},
  pages={209-213}
}
Spinal nerve ligation (SNL) results in a profound long lasting allodynia and increases in phosphorylated p38 in dorsal root ganglia (DRG) neurons and spinal cord microglia. We have previously shown that systemic etanercept, a tumor necrosis factor (TNF) antagonist, reduced allodynia by 42% and blocked SNL-induced increases in P-p38 levels in the L5 and L6 DRG, but not in the ipsilateral lumbar spinal cord. The present experiments demonstrated that intrathecal etanercept (100 microg) prevents… CONTINUE READING

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