Spinal astrocytes as therapeutic targets for pathological pain.

  title={Spinal astrocytes as therapeutic targets for pathological pain.},
  author={Takayuki Nakagawa and Shuji Kaneko},
  journal={Journal of pharmacological sciences},
  volume={114 4},
Development of next-generation analgesics requires a better understanding of the molecular and cellular mechanisms underlying pathological pain. Accumulating evidence suggests that the activation of glia contributes to the central sensitization of pain signaling in the spinal cord. The role of microglia in pathological pain has been well documented, while that of astrocytes still remains unclear. After peripheral nerve inflammation or injury, spinal microglia are initially activated and… CONTINUE READING
29 Citations
43 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 29 extracted citations


Publications referenced by this paper.
Showing 1-10 of 43 references

central processing of neuropathic pain

  • CJ Garrison, PM Dougherty, KC Kajander, SM. Carlton
  • Pharmacol Ther
  • 2010

Similar Papers

Loading similar papers…