Spinal and supraspinal contributions to central sensitization in peripheral neuropathy.

@article{Suzuki2005SpinalAS,
  title={Spinal and supraspinal contributions to central sensitization in peripheral neuropathy.},
  author={Rie Suzuki and Anthony Henry Dickenson},
  journal={Neuro-Signals},
  year={2005},
  volume={14 4},
  pages={175-81}
}
We will focus on spinal cord dorsal horn lamina I projection neurones, their supraspinal targets and involvement in pain processing. These spinal cord neurons respond to tonic peripheral inputs by wind-up and other intrinsic mechanisms that cause central hyper-excitability, which in turn can further enhance afferent inputs. We describe here another hierarchy of excitation - as inputs arrive in lamina I, neurones rapidly inform the parabrachial area (PBA) and periaqueductal grey (PAG), areas… CONTINUE READING