Spinal and supraspinal components of opioid antinociception in streptozotocin induced diabetic neuropathy in rats.

@article{Zurek2001SpinalAS,
  title={Spinal and supraspinal components of opioid antinociception in streptozotocin induced diabetic neuropathy in rats.},
  author={J R Zurek and Ray Nadeson and Colin S. Goodchild},
  journal={Pain},
  year={2001},
  volume={90 1-2},
  pages={57-63}
}
This study investigated the antinociceptive effect of opioids given via intraperitoneal and intrathecal routes in a diabetes-induced neuropathic pain model in rats. Streptozotocin induced diabetes in 91% of juvenile male Wistar rats at the dose of 150 mg/kg (75 mg/kg intraperitoneal on 2 successive days). When compared with younger weight-matched saline treated rats, the diabetic rats developed hyperalgesia assessed by the paw pressure nociceptive test. Nociceptive thresholds and responses to… CONTINUE READING
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