Spinal and supraspinal agmatine activate different receptors to enhance spinal morphine antinociception.

@article{Roerig2003SpinalAS,
  title={Spinal and supraspinal agmatine activate different receptors to enhance spinal morphine antinociception.},
  author={Sandra C. Roerig},
  journal={Annals of the New York Academy of Sciences},
  year={2003},
  volume={1009},
  pages={116-26}
}
The endogenous clonidine-displacing substance, agmatine, enhances morphine-induced antinociception and inhibits development of tolerance to morphine. Because agmatine binds with relatively high affinity to both alpha(2) adrenergic and imidazoline (I) receptors, the following studies were designed to determine which receptor type is involved in the morphine-enhancing activity. Mice were injected by various routes with agmatine, clonidine or norepinephrine as well as selective antagonists, and… CONTINUE READING

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