Spinal RyR2 pathway regulated by the RNA-binding protein HuD induces pain hypersensitivity in antiretroviral neuropathy

@article{Sanna2015SpinalRP,
  title={Spinal RyR2 pathway regulated by the RNA-binding protein HuD induces pain hypersensitivity in antiretroviral neuropathy},
  author={Maria Domenica Sanna and Daniele Peroni and Alessandro Quattrone and Carla Ghelardini and Nicoletta Galeotti},
  journal={Experimental Neurology},
  year={2015},
  volume={267},
  pages={53-63}
}
The antiretroviral toxic neuropathy, a distal sensory polyneuropathy associated with antiretroviral treatment, is a frequently occurring neurological complication during treatment of patients with AIDS and often leads to discontinuation of antiretroviral therapy. The mechanisms by which antiretroviral drugs contribute to the development of neuropathic pain are not known. Using drugs that reduce intracellular calcium ions (Ca(2+)), we investigated the hypothesis that altered cytosolic Ca(2… CONTINUE READING
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