Spinal NTS2 receptor activation reverses signs of neuropathic pain.

Abstract

Management of painful peripheral neuropathies remains challenging, since patients with chronic pain respond poorly to the available pharmacopeia. In recent years, the G-protein-coupled receptor neurotensin (NT) type 2 (NTS2) emerged as an attractive target for treating transitory pain states. To date, however, there is no evidence for its role in the… (More)
DOI: 10.1096/fj.12-225540

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