Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity.

@article{Lee2004SpinalNA,
  title={Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity.},
  author={Kyung-Min Lee and Bong-Seok Kang and Hye Lim Lee and Sun-Joo Son and Sung-Hun Hwang and D. Kim and Jae-Sik Park and H Y Cho},
  journal={The European journal of neuroscience},
  year={2004},
  volume={19 12},
  pages={3375-81}
}
Cyclooxygenase-2 (COX-2) is a major contributor to the elevation of spinal prostaglandin E2, which augments the processing of nociceptive stimuli following peripheral inflammation, and dynorphin has been shown to have an important role in acute and chronic pain states. Moreover, the transcription factor, nuclear factor-kappa B (NF-kB), regulates the expressions of both COX-2 and dynorphin. To elucidate the role of spinal NF-kB in the induction of inflammatory pain hypersensitivity, we examined… CONTINUE READING
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