Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury.

@article{Gu2016SpinalMD,
  title={Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury.},
  author={Nan Young Gu and Jiyun Peng and Madhuvika Murugan and Xi Wang and Ukpong B Eyo and Dongming Sun and Yi Ren and Emanuel Dicicco-Bloom and Wise Young and Hailong L. Dong and Long-Jun Wu},
  journal={Cell reports},
  year={2016},
  volume={16 3},
  pages={
          605-14
        }
}
Peripheral nerve injury causes neuropathic pain accompanied by remarkable microgliosis in the spinal cord dorsal horn. However, it is still debated whether infiltrated monocytes contribute to injury-induced expansion of the microglial population. Here, we found that spinal microgliosis predominantly results from local proliferation of resident microglia but not from infiltrating monocytes after spinal nerve transection (SNT) by using two genetic mouse models (CCR2(RFP/+):CX3CR1(GFP/+) and… CONTINUE READING
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