Spinal Astrocytic Activation Contributes to Mechanical Allodynia in a Rat Chemotherapy-Induced Neuropathic Pain Model

@inproceedings{Ji2013SpinalAA,
  title={Spinal Astrocytic Activation Contributes to Mechanical Allodynia in a Rat Chemotherapy-Induced Neuropathic Pain Model},
  author={Xi-tuan Ji and Niansong Qian and Tao Zhang and Jin-Mao Li and Xin-kui Li and Peng Wang and Dong-Sheng Zhao and Gang Huang and Lei Zhang and Zhou Fei and Dong Jia and Le Niu},
  booktitle={PloS one},
  year={2013}
}
Chemotherapy-induced neuropathic pain (CNP) is the major dose-limiting factor in cancer chemotherapy. However, the neural mechanisms underlying CNP remain enigmatic. Accumulating evidence implicates the involvement of spinal glia in some neuropathic pain models. In this study, using a vincristine-evoked CNP rat model with obvious mechanical allodynia, we found that spinal astrocyte rather than microglia was dramatically activated. The mechanical allodynia was dose-dependently attenuated by… CONTINUE READING