Spinal 5-HT7 Receptors Play an Important Role in the Antinociceptive and Antihyperalgesic Effects of Tramadol and Its Metabolite, O-Desmethyltramadol, via Activation of Descending Serotonergic Pathways

@article{Yanarate2010Spinal5R,
  title={Spinal 5-HT7 Receptors Play an Important Role in the Antinociceptive and Antihyperalgesic Effects of Tramadol and Its Metabolite, O-Desmethyltramadol, via Activation of Descending Serotonergic Pathways},
  author={Omer Yanarateş and Ahmet Bulent Dogrul and Vedat Yıldırım and Altan Şahin and Ali Sızlan and Melik Seyrek and {\"O}zg{\"u}r Akg{\"u}l and Orhan Kozak and Ercan Kurt and Ulku Aypar},
  journal={Anesthesiology},
  year={2010},
  volume={112},
  pages={696-710}
}
Background:Tramadol is an analgesic drug, and its mechanism of action is believed to be mediated by the &mgr;-opioid receptor. A further action of tramadol has been identified as blocking the reuptake of serotonin (5-HT). One of the most recently identified subtypes of 5-HT receptor is the 5-HT7 receptor. Thus, the authors aimed to examine the potential role of serotonergic descending bulbospinal pathways and spinal 5-HT7 receptors compared with that of the 5-HT2A and 5-HT3 receptors in the… 
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