Spina bifida

@article{Mitchell2004SpinaB,
  title={Spina bifida},
  author={L. Mitchell and N. Adzick and Jeanne Melchionne and P. Pasquariello and A. Whitehead},
  journal={The Lancet},
  year={2004},
  volume={364},
  pages={1885-1895}
}
  • L. Mitchell, N. Adzick, +2 authors A. Whitehead
  • Published 2004
  • Medicine
  • The Lancet
  • Spina bifida results from failure of fusion of the caudal neural tube, and is one of the most common malformations of human structure. The causes of this disorder are heterogeneous and include chromosome abnormalities, single gene disorders, and teratogenic exposures. However, the cause is not known in most cases. Up to 70% of spina bifida cases can be prevented by maternal, periconceptional folic acid supplementation. The mechanism underlying this protective effect is unknown, but it is likely… CONTINUE READING
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    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    The purpose of this investigation is to evaluate maternal and fetal outcomes following fetoscopic repair of fetal spina bifida at the Johns Hopkins Hospital. The hypothesis of… Expand
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    InterventionDevice
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    The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects.
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