Spina bifida

  title={Spina bifida},
  author={L. Mitchell and N. Adzick and Jeanne Melchionne and P. Pasquariello and A. Whitehead},
  journal={The Lancet},
  • L. Mitchell, N. Adzick, +2 authors A. Whitehead
  • Published 2004
  • Medicine
  • The Lancet
  • Spina bifida results from failure of fusion of the caudal neural tube, and is one of the most common malformations of human structure. The causes of this disorder are heterogeneous and include chromosome abnormalities, single gene disorders, and teratogenic exposures. However, the cause is not known in most cases. Up to 70% of spina bifida cases can be prevented by maternal, periconceptional folic acid supplementation. The mechanism underlying this protective effect is unknown, but it is likely… CONTINUE READING
    13 Citations

    Tables and Topics from this paper.

    Paper Mentions

    The purpose of this investigation is to evaluate maternal and fetal outcomes following fetoscopic repair of fetal spina bifida at the Johns Hopkins Hospital. The hypothesis of… Expand
    ConditionsChiari Malformation Type 2, Congenital Abnormality, Myelomeningocele, (+3 more)
    Fractures in spina bifida from childhood to young adulthood
    • 10
    Could autism with mental retardation result from digenism and frequent de novo mutations?
    • 6
    Shape analysis of the cervical spinous process
    • 5
    Mandatory Fortification of Flour with Folic Acid to Prevent Neural-Tube Defects
    • 4
    Comparison of Health-Related Quality of Life between children with cerebral palsy and spina bifida.
    • 12
    The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects.
    • 77


    Spinal and cranial neural tube defects.
    • J. McComb
    • Medicine
    • Seminars in pediatric neurology
    • 1997
    • 44
    Spina Bifida Outcome: A 25-Year Prospective
    • 540
    • PDF
    Surveillance for anencephaly and spina bifida and the impact of prenatal diagnosis--United States, 1985-1994.
    • J. Cragan, H. Roberts, +10 authors J. H. Dean
    • Medicine
    • MMWR. CDC surveillance summaries : Morbidity and mortality weekly report. CDC surveillance summaries
    • 1995
    • 123
    • PDF
    Evaluation of the lemon and banana signs in one hundred thirty fetuses with open spina bifida.
    • 179
    • Highly Influential
    Curly tail: a 50-year history of the mouse spina bifida model
    • 99
    Spina Bifida and Anencephalus in Greater London
    • 181
    • PDF
    Ultrasound Screening for Spina Bifida: Cranial and Cerebellar Signs in a High‐Risk Population
    • 83
    • Highly Influential