Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans

@inproceedings{MohdZin2017SpinaBP,
  title={Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans},
  author={Siti W Mohd-Zin and Ahmed I Marwan and Mohamad K Abou Chaar and Azlina Ahmad-Annuar and Noraishah Mydin Abdul-Aziz},
  booktitle={Scientifica},
  year={2017}
}
Spina bifida is among the phenotypes of the larger condition known as neural tube defects (NTDs). It is the most common central nervous system malformation compatible with life and the second leading cause of birth defects after congenital heart defects. In this review paper, we define spina bifida and discuss the phenotypes seen in humans as described by both surgeons and embryologists in order to compare and ultimately contrast it to the leading animal model, the mouse. Our understanding of… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

Manifestaciones neurológicas asociadas a espina bífida en adultos

C. Díaz Sanhueza, R. A. Pardo Vargas, P. Bustos
  • 2017

References

Publications referenced by this paper.
SHOWING 1-10 OF 313 REFERENCES

A randomized trial of prenatal versus postnatal repair of myelomeningocele

N. S. Adzick, E.A.Thom, C. Y. Spong
  • New England Journal of Medicine, vol. 364, no. 11, pp. 993–1004, 2011.
  • 2011
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Genetics of human neural tube defects

  • Human molecular genetics
  • 2009
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

The opposing roles of Wnt-5a in cancer

  • British Journal of Cancer
  • 2009
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Fetal surgery for myelomeningocele.

  • The New England journal of medicine
  • 2002
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL