Spin-trapping studies of the oxidation-reduction reactions of iron bleomycin in the presence of thiols and buffer.


The reaction of ferrous bleomycin with dioxygen is reexamined to clarify whether radical species derived from molecular oxygen are generated. Detection of low levels of spin-trapped oxyradicals confirm the production of OH during this reaction when bleomycin is present in excess, but not when iron and drug concentrations are equal. In phosphate buffer… (More)


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