Spin trapping of azidyl and hydroxyl radicals in azide-inhibited rat brain submitochondrial particles.

@article{Partridge1994SpinTO,
  title={Spin trapping of azidyl and hydroxyl radicals in azide-inhibited rat brain submitochondrial particles.},
  author={Robert Scott Partridge and Scott M. Monroe and Janice K Parks and Kimberly Welsh Johnson and Wayne D. Parker and Gareth R Eaton and Sandra S Eaton},
  journal={Archives of biochemistry and biophysics},
  year={1994},
  volume={310 1},
  pages={210-7}
}
Succinate-driven respiration in azide-inhibited rat brain submitochondrial particles (smps) produces azidyl and hydroxyl radicals that were detected by spin trapping with 5,5'-dimethyl-1-pyrroline-N-oxide (DMPO). Production of radicals required succinate and oxygen and was eliminated by heat denaturation, which indicates that radical production is a result of respiration. The concentrations of both DMPO/.OH and DMPO/.N3 were decreased by addition of catalase to the smps, which indicates that… CONTINUE READING
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